Above all, teachers need to inform themselves and the rest of the school community so that together they can develop a policy to discourage bullying. By educating themselves about bullying, teachers and parents have the knowledge to set up effective programmes and structures both within the classroom and for the whole school. Furthermore, by removing the opportunity for children to bully, providing children with a stimulating environment, and giving them the tools to deal with conflict appropriately, teachers can reduce children's inclination to bully. Although bullying will never be fully eradicated and must be dealt with as soon as it occurs, increasing awareness of the problem is making schools a safer and more enjoyable environment in which children can learn.
Approximately 86% and 60% of single somatic nucleotide variants (SSNVs) identified in synchronous nodal metastases and metachronous recurrent tumors, respectively, were transmitted from the primary index tumor. Genes that were mutated in more than one metastatic or recurrent tumor, but not in the respective primary tumors, include C17orf104, inositol 1,4,5-trisphosphate receptor, type 3 (ITPR3), and discoidin domain receptor tyrosine kinase 2 (DDR2). Select DDR2 mutations have been shown to confer enhanced sensitivity to SRC-family kinase (SFK) inhibitors in other malignancies. Similarly, HNSCC cell lines harboring endogenous and engineered DDR2 mutations were more sensitive to the SFK inhibitor dasatinib than those with WT DDR2.