Donation of tissues and organs, either post-surgery or post mortem, gives individuals and their families an opportunity to leave a meaningful legacy by providing the human specimens needed to advance research and development. Studies with human tissues and organs also serve as important alternatives to the use of live animals in research. By collaborating with the USA’s major organ procurement organizations, tissue banks, eye banks and medical centers, HTORR can provide nearly every anatomical structure, organ and tissue —both diseased and normal—to investigators in support of their research needs.
At left: OI-DIC image of a live mouse cell visualizing density of materials. The bright regions with the heart- and sphere-shapes are compartments in the cell called nucleoli. At right: A conventional fluorescence microscopy image of the same cell depicting only DNA. The bright regions are the heterochromatin. Some heterochromatin are marked with arrow heads for comparison between the two images. Note that they look different because the fluorescence image (right) does not necessarily show density of the materials. From Imai et al (2017) DOI: /-06-0359